Cancer of Unknown Primary (CUPs) provide a unique model to illustrate the fundamental functional principles of the metastatisation process, as well as the underlying genetic bases. Albeit far from being a rare tumour entity, they still represent an unsolved clinical problem, with elusive biology and paucity of effective therapies. The Conference will cover major aspects of CUPs and will put them in the context of cancer precision medicine.

The meeting will be structured in four sessions:
(1) CUPs: Drivers and Targets
(2) Cancer Stem Cells and CUPs: Understanding the Early Metastatic Phenotype
(3) CUPs: Diagnostic and Therapeutic Guidelines
(4) Cancer Precision Medicine in the Metastatic Disease